Table 2. Meta-analysis results of the associations between rs2241766 and rs1501299 polymorphisms in ADIPOQ gene and CAD risk in T2DM patients.
| Genetic model | NO. of studies | OR[95%CI] | Pmeta-analysis | Bon | FDR | I2 (%) | Paheterogeneity | Statistical method |
|---|---|---|---|---|---|---|---|---|
| rs2241766 | ||||||||
| G VS T | 12 | 1.18 [0.89, 1.56] | 0.260 | 1.000 | 0.613 | 80.00 | 0.000 | Random |
| GG VS GT+TT | 12 | 1.21 [0.56, 2.61] | 0.630 | 1.000 | 0.630 | 81.00 | 0.000 | Random |
| GG+GT VS TT | 12 | 1.11 [0.88, 1.39] | 0.390 | 1.000 | 0.613 | 68.00 | 0.000 | Random |
| GT VS TT | 12 | 1.08 [0.86, 1.37] | 0.490 | 1.000 | 0.613 | 52.00 | 0.030 | Random |
| GG VS TT | 12 | 1.33 [0.69, 2.55] | 0.400 | 1.000 | 0.613 | 72.00 | 0.000 | Random |
| rs1501299 | ||||||||
| T VS G | 10 | 0.86 [0.76, 0.98] | 0.020 | 0.100 | 0.033 | 46.00 | 0.060 | Fixed |
| TT VS TG+GG | 10 | 0.40 [0.22, 0.71] | 0.002 | 0.010 | 0.005 | 84.00 | 0.000 | Random |
| TT+TG VS GG | 10 | 0.95 [0.78, 1.16] | 0.600 | 1.000 | 0.600 | 63.00 | 0.003 | Random |
| TG VS GG | 10 | 0.95 [0.79, 1.13] | 0.530 | 1.000 | 0.600 | 45.00 | 0.070 | Fixed |
| TT VS GG | 10 | 0.67 [0.54, 0.83] | 0.000 | 0.002 | 0.002 | 36.00 | 0.120 | Fixed |
OR= odd ratio; CI= confidence interval.
a P value for between-study heterogeneity based on Q test;Bon= p value in Bonferroni test; FDR= false discovery rate.
Significant results are marked in bold.