FIG 3.

Conserved domain search results for TFIIS across the NCLDV. Orange, turquoise, and red bars represent motif superfamilies for the N-terminal, central, and C-terminal domains (domains I, II, and III), respectively, of TFIIS. Blue bar, poxvirus RP30 superfamily. The region of highest conservation between TFIIS and RP30 is the Zn ribbon-containing domain III (98), which is involved in transcript cleavage. This region is universally found among NCLDV TFIIS/RP30 homologs. Proteins are shown aligned according to the C terminus of this domain. “Yeast” refers to S. cerevisiae.