Table 2.
Multivariable disease specific survival analysis for PD-L1 expression quantified by percent positive & H-score
| Variable | Comparison | Risk ratio | 95%CI | p-value |
|---|---|---|---|---|
| PD-L1 H-Score | ||||
| PD-L1 H-Score | Per unit change | 1.01 | 0.997–1.02 | 0.10 |
| Age at Surgery | Per unit change | 1.01 | 0.991–1.02 | 0.44 |
| Sex | Male v Female | 1.14 | 0.85–1.53 | 0.37 |
| Adjuvant Chemotherapy | Given v Observation | 0.59 | 0.42–0.81 | 0.0011 |
| Histopathologic Grade | 1 v 2 | 0.63 | 0.10–2.10 | 0.50 |
| 1 v 3 | 0.49 | 0.08–1.67 | 0.28 | |
| 2 v 3 | 0.77 | 0.55–1.09 | 0.13 | |
| Lymphovascular Invasion | Present v Absent | 1.27 | 0.93–1.74 | 0.13 |
| Perineural Invasion | Present v Absent | 1.66 | 0.96–3.09 | 0.07 |
| pN-Stage | 1 v 0 | 1.83 | 1.27–2.68 | 0.0010 |
| Resection Status | R0 v R1 | 0.67 | 0.49–0.94 | 0.0202 |
| PD-L1 Percent Positive | ||||
| PD-L1 Percent Positive | Per unit change | 1.03 | 1.0005–1.05 | 0.0466 |
| Age at Surgery | Per unit change | 1.0006 | 0.99–1.02 | 0.42 |
| Sex | Male v Female | 1.16 | 0.86–1.55 | 0.33 |
| Adjuvant Chemotherapy | Given v Observation | 0.58 | 0.42–0.80 | 0.0008 |
| Histopathologic Grade | 1 v 2 | 0.64 | 0.10–2.13 | 0.51 |
| 1 v 3 | 0.50 | 0.08–1.71 | 0.30 | |
| 2 v 3 | 0.78 | 0.56–1.10 | 0.15 | |
| Lymphovascular Invasion | Present v Absent | 1.28 | 0.94–1.76 | 0.12 |
| Perineural Invasion | Present v Absent | 1.68 | 0.98–3.13 | 0.06 |
| pN-Stage | 1 v 0 | 1.85 | 1.28–2.71 | 0.0009 |
| Rescetion Status | R0 v R1 | 0.68 | 0.49–0.95 | 0.0189 |