Table 4.
Deep gray matter data: between group and between field strength comparisons
| MS group (n = 14) | NC group (n = 15) | pa, b MS vs NC | |||||||
|---|---|---|---|---|---|---|---|---|---|
| DGM structure | 1.5T | 3T | p (MS) 1.5T vs. 3T | 1.5T | 3T | P (NC) 1.5T vs 3T | 1.5T | 3T | |
| Volumes (ml) | Thalamus | 14.4 (1.4) 11.7–16.3 |
14.7 (1.5) 12.6–16.7 |
0.003 | 15.2 (1.0) 12.9–16.3 |
16.0 (1.0) 13.6–17.1 |
<0.0001 | 0.05 | 0.02 |
| Caudate | 6.2 (0.9) 4.9–7.8 |
6.5 (0.9) 5.0–8.2 |
0.0001 | 6.9 (0.8) 5.2–8.6 |
7.3 (0.9) 5.6–9.4 |
<0.0001 | 0.09 | 0.10 | |
| Putamen | 8.7 (0.7) 7.4–9.7 |
9.0 (0.7) 7.6–10.1 |
<0.0001 | 9.6 (0.8) 8.6–11.7 |
10.1 (0.9) 9.1–12.6 |
<0.0001 | 0.03 | 0.02 | |
| Globus pallidus | 2.9 (0.3) 2.4–3.4 |
3.1 (0.4) 2.6–3.9 |
0.0004 | 3.3 (0.3) 2.9–3.7 |
3.6 (0.3) 3.2–4.0 |
<0.0001 | 0.0006 | 0.0004 | |
| Total DGM | 32.2 (2.8) 26.4–37.1 |
33.4 (3.0) 28.1–38.6 |
<0.0001 | 35.0 (2.6) 30.9–40.2 |
37.0 (2.6) 32.8–42.8 |
<0.0001 | 0.02 | 0.01 | |
| Fractions | Thalamus | 0.011 (0.0011) 0.0087–0.013 |
0.012 (0.00097) 0.0096–0.013 |
0.12 | 0.0116 (0.00058) 0.010–0.013 |
0.012 (0.00063) 0.011–0.013 |
0.0004 | 0.31 | 0.23 |
| Caudate | 0.0049 (0.00057) 0.0037–0.0056 |
0.0051 (0.00058) 0.0040–0.0059 |
0.007 | 0.0053 (0.00046) 0.0040–0.0060 |
0.0055 (0.00053) 0.0043–0.0066 |
0.0004 | 0.20 | 0.30 | |
| Putamen | 0.0068 (0.00055) 0.0055–0.0078 |
0.0071 (0.00057) 0.0057–0.0080 |
0.0001 | 0.0074 (0.00051) 0.0065–0.0081 |
0.0077 (0.00053) 0.0068–0.0088 |
<0.0001 | 0.20 | 0.20 | |
| Globus pallidus | 0.0023 (0.00021) 0.0018–0.0026 |
0.0024 (0.00024) 0.0020–0.0028 |
0.0002 | 0.0025 (0.00017) 0.0023–0.0028 |
0.0028 (0.00013) 0.0025–0.0030 |
<0.0001 | 0.009 | 0.003 | |
| Total DGM | 0.0252 (0.0020) 0.0197–0.0282 |
0.0261 (0.0019) 0.0213–0.0280 |
0.002 | 0.0268 (0.0013) 0.0236–0.0290 |
0.0282 (0.0013) 0.0256–0.0299 |
<0.0001 | 0.11 | 0.07 | |
Key: Data are mean (standard deviation) on first line; range on second line; Percent differences between 1.5T and 3T are shown in Table 5; DGM = cerebral subcortical deep gray matter; MS multiple sclerosis, NC normal controls; aage adjusted; bthe differentiation (sensitivity) between MS and NC was similar for 1.5 versus 3T (all p > 0.05)