Table 3.

Prediction model and risk score calculation

Risk Factor	HR	95% CI	P value	Assigned score
Absence of AEa in first 4 weeks	1.60	(1.22, 2.11)	0.001	2
> 2 metastasis sites	1.62	(1.21, 2.17)	0.001	2
ECOG PS > 0	2.48	(1.70, 3.61)	< 0.001	3

HR hazard ratio, CI confidence interval, AE adverse event, ECOG PS Eastern Cooperative Oncology Group performance status

^aAdverse events (AE) are defined as hypertension, proteinuria, or hand and foot syndrome in the first 4 weeks of treatment