Fig. 3.

Tubulointerstitial lesion (TIL)-associated histological parameters in both glomerular lesions (GL) and TIL models. a Indices for the number of infiltrating B220⁺ B-cells, CD3⁺ T-cells, and Iba1⁺ macrophages in the model mice. b Indices for tubulointerstitial damage, including the area of αSMA⁺ myofibroblasts and the number of IL-1F6/IL-36α⁺ damaged tubules and CD34⁺ capillaries in the model mice. Values = mean ± SE. ^#: Significant difference from the control in the same disease group, Mann–Whitney U test (p < 0.05). ^* Significant difference from the other groups, Kruskal-Wallis test followed by Scheffe’s method (^* p < 0.05, ^** p < 0.01). N = 4. a, b, c, and d denote BXSB/MpJ, BXSB/MpJ-Yaa, Control, and UUO kidney, respectively