Table 2.
Correlation between CD34+ glomerular capillaries and histopathological parameters of glomeruli in GL and TIL model mice
| Parameters | Indices for glomerular histopathology | |||||||
|---|---|---|---|---|---|---|---|---|
| Glo. Size (μm2) | Cell number/glo. | Glo. damage score | B220+B-cells/Glo. | CD3+T-cells/Glo. | Iba1+macrophages/Glo. | CD34+ capillaries/Glo. | ||
| GL model | BXSB/MpJ | 3850 ± 116.35b# | 35.91 ± 1.40b# | 18.25 ± 9.8b# | 0.26 ± 0.03b# | 0.12 ± 0.04b# | 0.13 ± 0.02b# | 17.29 ± 0.87b# |
| BXSB/MpJ-Yaa | 6771.94 ± 446.32a#acd** | 71.85 ± 3.30a#acd** | 206.25 ± 36.29a# | 1.63 ± 0.57a#acd* | 1.79 ± 0.45a#acd* | 3.57 ± 0.40a#acd* | 9.68 ± 1.25a#ac* | |
| TIL model | Control kidney | 3161.13 ± 0.53b** | 31.88 ± 0.53b** | 0 | 0.18 ± 0.04b* | 0.13 ± 0.02b* | 0.07 ± 0.01b* | 13.3 ± 0.42b* |
| UUO kidney | 3010 ± 64.50b** | 31.31 ± 0.47b** | 0 | 0.22 ± 0.03b* | 0.08 ± 0.01b* | 0.03 ± 0.0b* | 12.56 ± 0.19 | |
Values = mean ± SE. #: Significant difference from the control in the same disease group, Mann–Whitney U test (p < 0.05). *Significant difference from the other groups, Kruskal-Wallis test followed by Scheffe’s method (* p < 0.05, ** p < 0.01). N = 4. Glo.: glomerular; Pod: podocyte; GLs: glomerular lesions; TILs: tubulointerstitial lesions
a, b, cand ddenotes BXSB/MpJ, BXSB/MpJ-Yaa, Control and UUO kidney, respectively