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. Author manuscript; available in PMC: 2017 Sep 5.
Published in final edited form as: Cancer Immunol Res. 2014 Aug 7;2(11):1059–1070. doi: 10.1158/2326-6066.CIR-14-0051

Figure 6. RNA GD2 CART-cells localize to, but do not infiltrate, disseminated tumors.

Figure 6

Animals with established disseminated tumors were sacrificed on days indicated and examined histologically after staining for human CD3. Black arrows indicate infusion of 1×107 T-cells. (A) With small tumors, some RNA GD2 CART-cells are able to penetrate and remain within tumor sites in the first 3 days of injection, however subsequent injections demonstrate peripheral localization without infiltration. (B) Initial passive infilatration by CD19 CART-cells is lost by day 3, and subsequent injections do not result in localization to tumor sites.