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. Author manuscript; available in PMC: 2017 Sep 5.
Published in final edited form as: Nat Rev Neurosci. 2011 Jan;12(1):31–42. doi: 10.1038/nrn2946

Figure 2. The spastin–Atlastin–REEP–Reticulon complex at the ER.

Figure 2

Receptor expression-enhancing proteins (REEPs; Yop1p in yeast) and Reticulon proteins form large oligomers, referred to here as morphogen complexes, to shape the tubular endoplasmic reticulum (ER) network. Atlastin proteins (Sey1p in yeast) interact with REEPs and Reticulons and are enriched in puncta along the tubules (shown by yellow circles), including at three-way junctions. A blown-out image of the axon shows a tubular ER three-way junction. A nested blown-out image of a presumptive ER morphogen complex depicts the proposed membrane topologies for proteins involved in generating curvature of ER tubules, as well as mediating microtubule interactions and fusion of ER tubules. AAA, ATPases associated with diverse cellular activities (AAA) ATPase domain; GTP, Atlastin GTPase domain; MIT, microtubule-interacting and trafficking protein domain; MBD, microtubule-binding domain; REEP, receptor expression-enhancing protein; Rtn, reticulon.