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SPIN binds and inhibits MPO. (A) An ELISA-type binding assay of C-His SPIN to all candidate proteins. AZU, azurocidin; CG, cathepsin G; LF, lactoferrin; MPO, myeloperoxidase; NE, neutrophil elastase; PR3, proteinase 3. (B) Characterization of SPIN binding to MPO by SPR, where SPIN was injected over a surface of native MPO. (C and D) Recombinant SPIN and S. aureus supernatant inhibit MPO in a dose-dependent manner. ON is overnight culture. Bars express SD with n = 3 for B–D.
