Fig. 3.

Immunogenicity of MERS S-2P in mice. (A) Reciprocal serum IC₉₀ neutralizing activity against autologous MERS England1 pseudotyped lentivirus reporter plotted against vaccine dose. (B) Reciprocal serum IC₉₀ neutralizing activity against multiple homologous MERS-CoV pseudoviruses of sera from mice immunized with 0.1 μg of protein. For both panels, the geometric mean IC₉₀ titer (GMT) of each group is represented by (A) symbols or (B) bars. Error bars represent geometric SDs. P values denoted as *P < 0.05 and **P < 0.01. The limit of detection for the assay is represented by dotted lines; for sera below the limit of detection a reciprocal IC₉₀ titer of 10 was assigned.