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Proline substitutions in S2 increase expression levels of coronavirus S proteins. (A and B) Expression levels of WT and proline-substituted S proteins from MERS-CoV (A) and SARS-CoV and HCoV-HKU1 (B) as assessed by SDS/PAGE. (C) Gel-filtration profiles of WT HCoV-HKU1 S (HKU1 S-WT) and stabilized HCoV-HKU1 S (HKU1 S-2P). Each protein was produced from 500 mL FreeStyle 293-F cells.
