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G4 Fab occupancy. (A and B) The MERS S-2P/G4 data contained two stoichiometric G4 classes. A majority of the data (69.6%) contained two G4 Fabs bound to the MERS S-2P spike (A), and the remaining data (30.4%) contained three bound G4 Fabs (B). (C and D) Stereo images of the G4 epitope. Epitopes that have G4 Fabs bound (C) are well-ordered whereas epitopes that remain unbound (D) exhibit a disordered loop.
