Table S2.

Parameters used to generate mouse and vole molar simulations

Parameter category	Parameter	Mouse	Vole
Iterations		14,000	14,000
Degradation	Deg (Protein degradation rate)	0.076	0.076
Growth factor	Set (Growth factor threshold)	0.95	0.95
	Sec (Growth factor secretion rate)	0.14	0.14
	Ds (Growth factor diffusion rate)	1.0	1.0
Activator	Act (Activators)	1.6	1.6
	Da (Activator diffusion rate)	0.2	0.2
	Lbi (Lingual bias)	1.34	0.4
	Bbi (Buccal bias)	1.31	0.0001
	Ina (Initial activator concentration)	0.0	0.0
Inhibitor	Int (Initial inhibitor threshold)	0.19	0.19
	Inh (Inhibitors)	800.0	800.0
	Di (Inhibitor diffusion rate)	0.2	0.2
Epithelium	Egr (Epithelial growth)	0.013	0.013
	Dgr (Downward vector of growth)	10,500.0	10,500.0
	Dff (Differentiation rate)	0.0002	0.0002
	Adh (Traction between neighbors)	0.005	0.005
	Rep (Young's modulus, stiffness)	1.5	1.5
	Ntr (Mechanical traction from the borders to the nucleus)	0.00013	0.00013
	Abi (Anterior bias)	3.2	8.0
	Pbi (Posterior bias)	7.0	5.0
Mesenchyme	Mgr (Mesenchymal growth)	16,000.0	16,000.0
	Bgr (Border growth amount in antero-posterior)	0.2	0.2
	Boy (Mesenchyme mechanic resistance)	0.17	0.17
Initial size	Rad (Radius of initial conditions)	3.0	3.0
	Swi (Distance from 0 where the borders are defined)	1.51	1.51
	Bwi (Width of border)	3.4	3.4

Parameters with different values in mouse and vole simulations are in bold. For parameters, see Materials and Methods and refs. 12 and 31. The model has the mouse parameter values as defaults (it can be downloaded at dead.cthulhu.fi/ToothMaker/).