Table S1.
mRNA mutation frequencies by mutation type of WT and mutant (E1103G and ▵RPB9) yeast
| Mutation type | RNA mutation frequency* | P value† | ||||
| WT | E1103G | ▵RPB9 | WT vs. E1103G | WT vs. ▵RPB9 | E1103G vs. ▵RPB9 | |
| Transitions | ||||||
| A→G | 2.15E-06 | 3.00E-06 | 3.22E-06 | — | — | — |
| U→C | 8.39E-06 | 3.66E-05 | 1.80E-05 | 2.20E-16 | 2.55E-09 | 6.66E-14 |
| G→A | 4.81E-06 | 4.95E-05 | 9.32E-05 | 2.20E-16 | 2.20E-16 | 2.20E-16 |
| C→U | 1.32E-04 | 1.31E-04 | 1.49E-04 | — | 6.55E-03 | 1.59E-03 |
| Transversions | ||||||
| G→C | 1.79E-06 | 1.90E-06 | 3.83E-06 | — | — | — |
| C→G | 6.27E-07 | 6.47E-07 | 1.75E-06 | — | — | — |
| A→C | 2.08E-07 | 5.34E-07 | 4.20E-07 | — | — | — |
| U→G | 6.62E-07 | 5.30E-07 | 1.02E-06 | — | — | — |
| A→U | 6.24E-07 | 1.03E-06 | 1.40E-06 | — | — | — |
| U→A | 8.83E-07 | 3.53E-06 | 8.42E-06 | 2.20E-06 | 2.20E-16 | 3.39E-07 |
| G→U | 3.34E-05 | 2.97E-05 | 3.83E-05 | — | — | 2.66E-03 |
| C→A | 7.16E-07 | 2.21E-06 | 4.56E-06 | 3.47E-03 | 3.83E-07 | 4.97E-03 |
| Indels | ||||||
| Insert | 2.39E-06 | 3.88E-06 | 4.13E-06 | 6.41E-06 | 5.50E-05 | — |
| Delete | 2.19E-06 | 1.70E-06 | 1.68E-06 | — | — | — |
*
Mutation frequency is total RNA mutations over all nucleotides sequenced.
†
P values were calculated by the two-sample test for equality of proportions with continuity correction. P values >0.01 not shown for clarity.