Table S3.
Mutation types induced in mRNA upon oxidative stress treatment
| Mutation type | mRNA mutation frequency* | Fold change | P value† | |
| Ctrl | H2O2 | |||
| Transitions | ||||
| A→G | 3.34E-06 | 9.35E-06 | 2.8 | — |
| U→C | 7.87E-06 | 1.27E-05 | 1.6 | — |
| G→A | 1.93E-06 | 1.54E-04 | 80 | 2.20E-16 |
| C→U | 2.01E-04 | 2.31E-04 | 1.2 | — |
| Transversions | ||||
| G→C | 2.23E-06 | 1.85E-05 | 8.3 | 5.23E-04 |
| C→G | 4.60E-06 | 1.26E-05 | 2.7 | — |
| A→C | 7.84E-07 | 1.40E-05 | 18 | 1.16E-07 |
| U→G | 5.32E-08 | 4.24E-06 | 80 | 4.15E-04 |
| A→U | 6.79E-07 | 0.00E+00 | — | — |
| U→A | 4.26E-07 | 1.27E-05 | 30 | 3.87E-12 |
| G→U | 2.61E-05 | 3.09E-05 | 1.2 | — |
| C→A | 3.34E-07 | 5.47E-05 | 164 | 2.20E-16 |
| Indels | ||||
| Insert | 1.88E-06 | 5.89E-06 | 3.1 | 0.02 |
| Delete | 2.21E-06 | 5.89E-06 | 2.7 | — |
*
Mutation frequency is total RNA mutations over all nucleotides sequenced.
†
P values were calculated by the two-sample test for equality of proportions with continuity correction. P values >0.05 not shown for clarity.