Table S4.
Mutation types induced in rRNA upon oxidative stress treatment
| Mutation type | rRNA mutation frequency* | Fold change | P value† | |
| Ctrl | H2O2 | |||
| Transitions | ||||
| A→G | 3.80E-06 | 1.86E-05 | 4.9 | 4.19E-07 |
| U→C | 4.49E-06 | 2.47E-05 | 5.5 | 1.95E-10 |
| G→A | 3.02E-06 | 6.41E-05 | 21 | 2.20E-16 |
| C→U | 5.36E-05 | 2.09E-04 | 3.9 | 2.20E-16 |
| Transversions | ||||
| G→C | 2.26E-06 | 1.25E-05 | 5.5 | 7.98E-06 |
| C→G | 3.48E-06 | 1.02E-05 | 2.9 | — |
| A→C | 8.41E-07 | 1.86E-06 | 2.2 | — |
| U→G | 4.59E-07 | 1.14E-05 | 25 | 2.20E-16 |
| A→U | 1.27E-06 | 2.05E-05 | 16 | 2.20E-16 |
| U→A | 7.91E-07 | 1.33E-05 | 17 | 2.20E-16 |
| G→U | 1.76E-05 | 8.01E-05 | 4.6 | 2.20E-16 |
| C→A | 2.81E-07 | 6.11E-05 | 217 | 2.20E-16 |
| Indels | ||||
| Insert | 9.01E-07 | 3.47E-06 | 3.9 | 7.24E-04 |
| Delete | 1.46E-06 | 8.43E-06 | 5.8 | 3.22E-14 |
*
Mutation frequency is total RNA mutations over all nucleotides sequenced.
†
P values were calculated by the two-sample test for equality of proportions with continuity correction. P values >0.05 not shown for clarity.