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Parametric linkage of rare SMAD6 alleles to craniosynostosis under single locus and 2 locus models incorporating BMP2 risk alleles
| Genotype (SMAD6; BMP2) | Penetrance in two-locus model (SMAD6/BMP2) | Penetrance in single-locus model (SMAD6) |
| +,D; C,C | 1 | 0.12 |
| +,D; C,T | 0.85 | 0.12 |
| +,D; T,T | 0.07 | 0.12 |
| +,+; C,C | 0.0032 | 0.0032 |
| +,+; C,T | 0.0008 | 0.0008 |
| +,+; T,T | 0.0002 | 0.0002 |
