Figure 5.

Regulation of lncRNA expression by NRL. (A) NRL-centered lncRNA expression network. NRL targets represent lncRNAs that are differentially expressed in the RNA-seq data from WT rods vs Nrl^−/− S-cone like photoreceptors and exhibit a significant NRL binding site within the putative promoter region. Only top 50% of network is represented here. (B) Schematic representation of the gene structure of two known (Gm14268 and Gm14216) and two unannotated lncRNA (XLOC_075365 and XLOC_074863) targets of NRL. The ChIP-seq peaks for NRL and CRX are shown by histograms (highlighted by dashed box) and overlap with the transcription start site (TSS) of the two genes, indicated in histograms for RNA-seq and individual sequence reads.