Table 1. Pharmacodynamic interaction concentration index (FICi) between F-diRhls and CAS, ITR or VTR for A. fumigatus ku80.
| MECa or MICb drugs alone | MEC or MIC drugs in combination | ∑FICmin, ∑FICmax indexc | |||||||
|---|---|---|---|---|---|---|---|---|---|
| F-diRhls (mm) | CAS (μg ml−1) | ITR (μg ml−1) | VRC (μg ml−1) | F-diRhls, CAS | F-diRhls, ITR | F-diRhls, VRC | F-diRhls, CAS | F-diRhls, ITR | F-diRhls, VRC |
| 4 | 0.25 | 16 | 0.3 | 1, 1 | 2, 1 | 1, 0.063 | 2.2, 4.25 | 0.56, 0.5 | 0.5, 0.56 |
Abbreviations: CAS, caspofungin; diRhls, dirhamnolipids; ITR, itraconazole; MEC, minimal effective concentration; VTR, voriconazole.
a
MEC for F-diRhls and CAS.
b
MIC for itraconazole and voriconazole.
c
FICi ∑FICmin <1 = synergy; FICi ∑FICmax >1.25 = antagonism; 1< FIC <1.25 = additive.