Table 1. Haplotypes generated using 4 SNPs located downstream of the SEA deletion α0-thalassemia in Southeast Asian populations investigated as compared to other populations described in the HapMap project.
| rs1211375 | rs3918352 | rs1203974 | rs11248914 |
(αα) Allele frequency, % |
(—SEA) Allele frequency, % |
|||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
|
Asia |
Europe |
Africa | America |
Asia |
||||||||||||||
| THAa | LAOa | CAMa | CHBb | JPTb | GIHb | CEUb | TSIb | YRIb | MEXb | THAa | LAOa | CAMa | CHNc | |||||
| Haplotype | A>C | A>G | A>G | C>T | (n=119) | (n=76) | (n=35) | — | — | — | — | — | — | — | (n=73) | (n=28) | (n=7) | (n=30) |
| H1 | A | A | A | T | 44.9 | 32.9 | 39.6 | 34.5 | 36.6 | 31.2 | 26.1 | 29 | 19.2 | 3.12 | ||||
| H2 | C | G | G | C | 24.4 | 25.3 | 14.2 | 35.7 | 30.8 | 11.4 | 9.8 | 11.4 | 3.9 | 26 | ||||
| H3 | C | A | A | C | 17.2 | 12.4 | 17.2 | 14.3 | 22.1 | 24.4 | 10.5 | 11.9 | 27.8 | 17.3 | ||||
| H4 | A | A | G | C | 6.7 | 11.9 | 14.3 | 10.7 | 5.8 | 1.1 | 94.05 | 100 | 100 | 100 | ||||
| H5 | C | A | A | T | 2.8 | 5.6 | 5.7 | 2.4 | 2.3 | 1.5 | 1.1 | 23 | ||||||
| H6 | C | G | G | T | 2.3 | 6.2 | 5.7 | 1.2 | 1.7 | 18.7 | 35.6 | 31.2 | 10 | 26.9 | ||||
| H7 | C | G | A | C | 5.2 | 1.2 | 6.8 | 7.1 | 6.8 | 4.8 | ||||||||
| H8 | A | G | A | C | 2.3 | 6.3 | 5.7 | |||||||||||
| H9 | A | A | G | T | 27 | |||||||||||||
| H10 | C | G | A | T | 3 | |||||||||||||
| H11 | A | G | G | T | 2.6 | |||||||||||||
| H12d | A | A | A | C | 1.8 | 3 | 1.9 | 2.83 | ||||||||||
a
Populations under study; THA (Thai), LAO (Laotian), CAM (Cambodian).
b
Data taken from the HapMap project; CHB (Han Chinese in Beijing, China), JPT (Japanese in Tokyo, Japan), GIH (Gujarat Indians in Houston, TX, USA), CEU (Utah residents with Northern and Western European ancestry), TSI (Toscans in Italy), YRI (Yoruba Ibadan, Nigeria) and MEX (Mexican ancestry in Los Angeles).
c
From Qiu QW, et al., BMC Evolutionary Biology 2013; 13: 63. CHN (Chinese).
d
Ancestral haplotype.