Table 2. Derived allele frequencies of five SNPs surrounding the SEA deletion α0-thalassemia in normal and α0-thalassemia carrier in Thai population.
Derived allele frequencies |
|||||
---|---|---|---|---|---|
SNP ID | Polymorphisma | Positionb | SEA carrier (n=59) | Normal (n=30) | P-valuec |
rs3760053 | T>G | 161244 | 0.4831 | 0.0333 | < 0.001 |
rs1211375 | A>C | 190281 | 0.2881 | 0.4667 | 0.100 |
rs3918352 | A>G | 197889 | 0.2034 | 0.2667 | 0.511 |
rs1203974 | A>G | 227459 | 0.6694 | 0.3333 | 0.002 |
rs11248914 | C>T | 243563 | 0.2712 | 0.5000 | 0.002 |
Abbreviation: SNP, single-nucleotide polymorphism.
Allele on the positive strand and the first character represents an ancestral allele.
NCBI position in chromosome 16.
By Fisher’s exact test.