Table 3. −2 Log-Likelihood of each covariate model tested.

Covariates included in model	−2 Log-Likelihood
Non BSA normalized base model	376.03
BSA normalized base model	312.34
rs2295890	301.21
Age	299.16
Diagnosis	289.87
rs2295890, age	289.35
Diagnosis, age	281.38
Diagnosis, rs2295890	277.43
Final model: diagnosis, rs2295890, age	262.51

The categorical covariates are defined as follows: rs2295890=(0—WT or 1—heterozygous variant or Mutant); Diagnosis=(0—AA/SAA/VSAA (aplastic anemia) or 1—FA (Fanconi Anemia)). The covariates diagnosis and rs2295890 are included on the clearance and the covariate age is included on volume and the inter-compartmental parameter k₂₁.