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. 2017 May 18;8(5):e2793. doi: 10.1038/cddis.2017.202

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Copyright © 2017 The Author(s)

Cell Death and Disease is an open-access journal published by Nature Publishing Group. This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/

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The DNA damage response is not involved in ACOT7 depletion-mediated cytostasis. (a–d) After transfection of ACOT7 Si (a and d), or after exposure to 6 Gy IR (b), or after treatment with 50 ng/ml Doxo (c), MCF7 cells were harvested at the indicated time intervals. Western blotting analysis was performed with anti-phospho ATM and anti-γH2AX. (e) Immunocytochemical staining of γH2AX (green) was conducted at 1 day after transfection of ACOT7 Si. DNA was counterstained with DAPI (blue). Cells exposed to 6 Gy of IR were used as the positive control (PC)