Fig. 1.

CCN2 and LRP6 are up-regulated in human HCC and invasive HCC cell Lines. a CCN2 and LRP6 mRNA expression in 96-paired HCC non tumor tissues. b Protein expression of CCN2 and LRP6 in tumor tissues (T) and adjacent nontumor tissues (N). c Representative immunostaining pictures of CCN2 and LRP6 in HCC patients. d Bar graph shows statistics for staining intensity in training (N = 144) and validation cohort (N = 374). e Relative CCN2 and LRP6 mRNA and protein levels in HCC cell lines and normal liver cell line L-02, and GAPDH was used as a loading control