Fig. 7.

Low molecular weight heparin sodium (LMWHs) inhibited tumor growth, especially in cell lines that exhibit high expression of CCN2, and combination treatment with LMWHs and oxaliplatin resulted in an enhanced chemotherapeutic effect. a Proliferation was assessed for MHCC97H cells that were treated with LMWHs (2 U/mL) for 24, 48, 72, or 96 h with or without oxaliplatin. b, c Tumor proliferation was examined in mouse xenografts established with MHCC97H cells with high expression of CCN2 or with low expression of CCN2, and then treated with LMWHs or with LMWHs and oxaliplatin