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. Author manuscript; available in PMC: 2017 Sep 5.
Published in final edited form as: Leuk Res. 2014 Sep 10;38(11):1332–1341. doi: 10.1016/j.leukres.2014.09.001

Figure 3. SGI-110 treatment induces hypomethylation and expression of NY-ESO-1 and MAGE-A3/A6 in U937 xenografts treated using a weekly x 3 schedule.

Figure 3

SGI-110 at varying doses (6.1, 12.2, 24.4 mg/kg) or DAC (5mg/kg) was administered once weekly for three weeks (days 1, 8, 15); on day 20 after treatment, tumors were harvested. A) LINE-1 and NY-ESO-1 promoter methylation by bisulfite pyrosequencing; MAGE-A3/6 by MSP (Representative of two experiments). B) NY-ESO-1 and MAGE-A3/6 mRNA by qRT-PCR. C) NY-ESO-1 and MAGE-A protein expression by western blotting. Data represent 3 animals/group. *p<0.05 vs. vehicle; **p<0.05 vs. DAC.