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. Author manuscript; available in PMC: 2017 Sep 5.
Published in final edited form as: Leuk Res. 2014 Sep 10;38(11):1332–1341. doi: 10.1016/j.leukres.2014.09.001

Table 1.

SGI-110 toxicity in vivo

Groups Treatment mg/kg/d Toxicity
G1–5 Vehicle 5/5 mice were alive till endpoint
SGI-110-3 2/5 mice were found slightly hunched
SGI-110-6.1 5/5 mice showed gas filled intestines
SGI-110-10 4/5 mice were dead on the day of endpoint. 1 mouse was moribund
DAC-2.5 2/5 mice were slightly hunched and showed gas filled intestines
G6–10 Vehicle 5/5 mice were alive till endpoint
SGI-110-6.1 5/5 mice were alive till endpoint
SGI-110-12.2 5/5 mice were alive till endpoint
SGI-110-24.4 5/5 mice were alive till endpoint
DAC-5 5/5 mice were alive till endpoint
G11–15 Vehicle 5/5 mice were alive till endpoint
SGI-110-6.1 1/5 mouse was dead
SGI-110-12.2 1/5 mouse was found dead and remaining 4 tissue samples were harvested before the completion of last two treatments as the mice were sick.
SGI-110-24.4 1/5 mouse was found dead and rest 4 mouse tissue samples were harvested before the completion of last two treatment as they were moribund or sick.
DAC-2.5 5/5 mice were alive till endpoint