Table 1.
Baseline Characteristics Across AFEQT Summary Score Quartiles
| Overall N=2007 |
Quartile 10.0-65.7 N=497 (Worst QoL) |
Quartile 266.7-81.5 N=507 |
Quartile 381.9-93.1 N=501 |
Quartile 493.5-100.0 N=502 (Best QoL) |
P-Value | |
|---|---|---|---|---|---|---|
| Age (years)* | 76 (67-82) | 73 (66-81) | 74 (67-81) | 75 (67-82) | 78 (70-83) | <0.0001 |
| Female | 866 (43.2) | 251 (50.5) | 222 (43.8) | 212 (42.3) | 181 (36.1) | <0.0001 |
| Race | 0.0369 | |||||
| White | 1805 (89.9) | 449 (90.3) | 453 (89.4) | 453 (90.4) | 450 (89.6) | |
| Black | 116 (5.8) | 29 (5.8) | 25 (4.9) | 28 (5.6) | 34 (6.8) | |
| Hispanic | 53 (2.6) | 7 (1.4) | 21 (4.1) | 9 (1.8) | 16 (3.2) | |
| Other | 28 (1.4) | 10 (2.0) | 8 (1.6) | 9 (1.8) | 1 (0.2) | |
| Past Medical History | ||||||
| Hypertension | 1657 (82.6) | 429 (86.3) | 423 (83.4) | 402 (80.2) | 403 (80.3) | 0.0317 |
| Diabetes | 554 (27.6) | 159 (32.0) | 133 (26.2) | 135 (27.0) | 127 (25.3) | 0.0819 |
| OSA | 405 (20.2) | 131 (26.4) | 119 (23.5) | 88 (17.6) | 67 (13.4) | <0.0001 |
| CAD | 631 (31.4) | 172 (34.6) | 154 (30.4) | 164 (32.7) | 141 (28.1) | 0.1337 |
| Heart Failure | 548 (27.3) | 168 (33.8) | 151 (29.8) | 119 (23.8) | 110 (21.9) | <0.0001 |
| Stroke | 178 (8.9) | 43 (8.7) | 39 (7.7) | 51 (10.2) | 45 (9.0) | 0.5793 |
| Implanted Device | ||||||
| ICD | 98 (4.9) | 27 (5.4) | 27 (5.3) | 20 (4.0) | 24 (4.8) | 0.7019 |
| CRT-P | 15 (0.8) | 4 (0.8) | 5 (1.0) | 3 (0.6) | 3 (0.6) | 0.8701 |
| CRT-D | 63 (3.1) | 15 (3.0) | 16 (3.2) | 17 (3.4) | 15 (3.0) | 0.9829 |
| BMI (kg/m2) | 28.8 (25.4, 33.7) | 30.2 (26.3, 36.3) | 29.0 (25.1, 34.3) | 28.8 (25.3-33.1) | 28.0 (25.0-32.4) | <0.0001 |
| Heart Rate (bpm) | 70 (63-79) | 72 (64-80) | 70 (64-80) | 70 (63-76) | 70 (61-76) | 0.0167 |
| Systolic Blood Pressure (mmHg) | 126 (118-138) | 125 (114-136) | 126 (118-138) | 124 (116-138) | 128 (118-138) | 0.0788 |
| Diastolic Blood Pressure (mmHg) | 72 (67-80) | 72 (66-80) | 72 (66-80) | 72 (67.5-80) | 72 (68-80) | 0.6847 |
| Calculated CrCl (mL/min/1.73m2) | 68.2 (50.0-94.9) | 72.3 (52.3-104.0) | 68.6 (49.2-94.9) | 68.0 (49.9-93.7) | 65.0 (49.3-87.0) | 0.0062 |
| LVEF (%) | 56 (50-61) | 55 (50-60) | 55 (50-62) | 58 (50-62) | 60 (50-64) | 0.0210 |
Values are presented as N (%) or median (interquartile range) unless otherwise specified.
Creatinine clearance calculated using the Cockroft-Gault formula and does not include patients on dialysis.
QoL: Quality of Life; OSA: Obstructive Sleep Apnea; CAD: Coronary Artery Disease; ICD: Implantable Cardioverter Defibrilation; CRT-P: Cardiac Resynchronization Therapy Pacemaker; CRT-P Cardiac Resynchronization Therapy Defibrillator; CrCl: creatinine clearance; LVEF: left-ventricular ejection fraction