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. Author manuscript; available in PMC: 2018 Aug 4.
Published in final edited form as: J Mol Biol. 2017 Jul 8;429(16):2528–2541. doi: 10.1016/j.jmb.2017.07.001

Table 1.

Binding affinities

Sample FcγRI Kinetic
KD (nM)		 FcγRIIA 167H
Steady State
KD (nM)		 FcγRIIA 167R
Steady State
KD (nM)		 FcγRIIB Steady
State KD (nM)		 FcγRIIIA 176F
Steady State
KD (nM)		 FcγRIIIA 176V
Steady State KD
(nM)
WT 3 1148 8015 3516 4538 1703
N297Q 295 n.d. n.d. n.d. n.d. n.d.
SGTA 222 996 >10,000 6447 n.d. n.d.
DTT-IYG 5 n.d. 2730 n.d. 1807 1040
DAT-IYG 29 n.d. >10,000 4169 2227 1051
HAT-IYG 216 n.d. n.d. n.d. 1680 1793
299A-IYG 243 605 2494 2101 1244 452
hIgG1 3 1095 5160 6499 710 348
*

n.d. not detectable