Table 3.
Nominal Logistic Regression of Variables Associated With Hematoma Expansiona
| Variable | Lobar ICH (n = 193) | Deep ICH (n = 128) | ||
|---|---|---|---|---|
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| Adjusted OR (95% CI) | P Value | Adjusted OR (95% CI) | P Value | |
| Age | 0.95 (0.91–0.99) | .03 | 1 (0.96–1.05) | .87 |
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| Female | 1.36 (1–1.5) | .19 | 1.45 (1–1.6) | .22 |
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| Acute-Phase CT Features | ||||
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| Time to final CT ≤6 vs >6 hb | 2.54 (1.39–5.14) | <.001 | 1.69 (0.73–5.08) | .27 |
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| Presence of spot sign | 2.27 (1.11–4.15) | .02 | 1.66 (1–3.38) | .02 |
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| Baseline IVH | 0.92 (0.53–1.54) | .75 | 1.66 (0.97–3.1) | .09 |
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| Baseline ICH volumec | 0.59 (0.07–5.16) | .63 | 0.74 (0.4–1.31) | .30 |
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| MRI SVD Markers | ||||
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| WMH volumec | 1 (0.98–1.01) | .77 | 1.01 (1–1.2) | .47 |
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| Absence of CMBs | 1.70 (1.07–2.92) | .04 | 1.18 (0.73–2.38) | .59 |
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| Presence of cortical superficial siderosis | 1.50 (0.89–2.38) | .11 | NA | NA |
Abbreviations: CMBs, cerebral microbleeds; CT, computed tomographic; ICH, intracerebral hemorrhage; IVH, intraventricular hemorrhage; MRI, magnetic resonance imaging; NA, not applicable; OR, odds ratio; SVD, small vessel disease; WMH, white matter hyperintensity.
a
Hematoma expansion was defined as a volume increase of 6mL or 33% between baseline and follow-up imaging. The adjusted OR is for the presence of significant hematoma expansion. For continuous dependent variables, the OR is over the entire range.
b
See the Methods section, Computed Tomography subsection, for definition of this term.
c
Variable was log-transformed in the multivariable model.