. Author manuscript; available in PMC: 2018 Feb 1.

Published in final edited form as: Bioorg Med Chem Lett. 2016 Dec 2;27(3):620–625. doi: 10.1016/j.bmcl.2016.12.002

Table 1.

Partial hydrogenation of poly-yne compound 17 to the corresponding alkene methyl ester 18.

	17	18	Time (h)^a	Yield (%)
I	100 mg (0.3 mmol)	40 mg	18	43^b
II	500 mg (1.6 mmol)	250 mg	28	48

reaction condition: Lindlar catalyst, 2-methyl-2-butene:MeOH:pyridine (4:4:1), room temperature, H₂ gas (1 atm),

average yield in duplicates