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. Author manuscript; available in PMC: 2018 Jul 26.
Published in final edited form as: Cell Syst. 2017 Jul 26;5(1):25–37.e3. doi: 10.1016/j.cels.2017.06.014

Figure 3. Transcription Factor Motif and Pathway Analysis of TLR Non-additive Response Genes.

Figure 3

(A and B) DiRE analysis of enriched transcriptional regulatory motifs at the promoter and promoter + distal regions of (A) synergized and (B) antagonized gene clusters as identified in Figure 2B. Members of recurrent NF-kB, AP1, IRF, STAT, and ETS transcription factor families are highlighted.

(C) Ingenuity pathway analysis (IPA) functional annotation of genes within the synergized and antagonized gene clusters as identified in Figure 2B.