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. Author manuscript; available in PMC: 2018 Oct 1.
Published in final edited form as: Food Chem Toxicol. 2017 Aug 18;108(Pt A):339–350. doi: 10.1016/j.fct.2017.08.020

Figure 1. Time course and dose response of liver injury after acetaminophen treatment.

Figure 1

Mice were treated with 200 or 300 mg/kg acetaminophen (APAP) and sacrificed at various time points between 0 and 96h. (A) Plasma alanine aminotransferase (ALT) activity. (B) Areas of necrosis (%). (C) Representative H&E-stained liver sections (original magnification 50×) after 300 mg/kg APAP with necrotic areas outlined. Necrotic areas were identified by lack of nuclear staining or pyknotic nuclei and lines were marked along the boundaries. Data are expressed as mean ± SEM for n = 4–6 animals per group and time point.