Skip to main content
. Author manuscript; available in PMC: 2018 Jul 1.
Published in final edited form as: Expert Opin Drug Deliv. 2016 Oct 11;14(7):865–877. doi: 10.1080/17425247.2017.1243527

Figure 3.

Figure 3

Priming strategies for drug delivery. A) Suppression of resident macrophages in the liver and spleen reduces nanoparticle uptake in these organs. B) Inhibition of the complement system may reduce nanoparticle recognition and clearance by the mononuclear phagocyte system (MPS). C) Vascular normalization agents improve nanoparticle extravasation. D) Mild hypothermia increases vascular permeability. E) Suppression of fibroblasts reduces the production of extracellular matrix (ECM) components. F) Tumor cell apoptosis expands the interstitial space, leading to improved intratumoral distribution of nanoparticles. G) Degradation of ECM components improves the diffusion of nanoparticles in the interstitium.