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A model for the role of HDAC4 during C2C12 differentiation. In myoblasts HDAC4 is held in the cytoplasm, where it associates with 14-3-3 proteins in a phosphorylation-dependent manner. Cytoplasmic retention of HDAC4, which is stimulated by CaMKIV activity, allows MEF2-dependent transcriptional activation via CBP/p300 histone acetyltransferases. After myotube fusion HDAC4 relocates to the nucleus, where it associates with MEF2 to repress transcription.
