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. 2017 Aug 26;12:6239–6257. doi: 10.2147/IJN.S143293

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© 2017 Li et al. This work is published and licensed by Dove Medical Press Limited

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(A, B) Cytotoxicity of NPs detected by MTT assays. Effects of MSNs@PDA-PEG, free DM1, MSNs-DM1@PDA-PEG, and MSNs-DM1@PDA-PEG-APt on NCM460 cell (A) and SW480 cell (B) proliferation, assessed by MTT assay after 12, 24, and 48 hours of treatment, respectively. Data are expressed as mean ± SD (*P<0.05, **P<0.01). (C) BrdU incorporation assay by confocal microscopy (red, BrdU; blue, DAPI; scale bar =10 µm).

Abbreviations: NC, negative control; MSNs, mesoporous silica nanoparticles; PDA, hydrochloride dopamine; PEG, polyethylene glycol; APt, aptamer; DAPI, 4′-6′-diamino-2-phenylindole hydrochloride; NPs, nanoparticles; MTT, 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide; SD, standard deviation; BrdU, bromodeoxyuridine.