Table 2.

Oxidative stress parameters and PAI in the presence and absence of pain, median (quartiles)

	No pain	Pain#	p-value*
Endodontium
PAI	2.0 (1.0–4.0)	4.0 (2.0–5.0)	<0.001
MPO (ng/mg protein)	27.9 (5.6–100.9)	72.6 (39.2–111.2)	0.004
OSI	6.0 (3.6–8.9)	10.4 (6.6–14.9)	<0.001
8-EPI (pg/mL)	50.0 (36.0–67.5)	75.0 (56.1–122.4)	<0.001
Saliva
MPO (ng/mg protein)	34.2 (11.1–126.0)	117.5 (76.0–190.9)	<0.001
OSI	7.2 (4.1–12.0)	8.0 (3.6–10.6)	NS
8-EPI (pg/mL)	50.0 (35.0–55.0)	112.8 (60.3–210.0)	<0.001

Notes:

^*Mann–Whitney rank sum test was used.

^#Current pain or pain in recent anamnesis.

Abbreviations: MPO, myeloperoxidase; OSI, oxidative stress index; PAI, periapical index; 8-EPI, 8-isoprostanes; NS, not significant.