Table 2. Antimicrobial activity of NCL195 against Gram-negative bacteria alone and in combination with EDTA or polymyxin B.
| Bacterial strain | Agent | Combination | |||||
|---|---|---|---|---|---|---|---|
| EDTA (mM) | Polymyxin B (μg/ml) | NCL195 (μg/ml) | EDTA (mM) | NCL 195 (μg/ml) | Polymyxin B (μg/ml) | NCL 195 (μg/ml) | |
| A. baumannii ATCC 12457 | 0.5 | 0.5 | >128 | 0.25 | 4 | 0.125 | 0.5 |
| A. baumannii ATCC 19606 | 1 | 0.5 | >128 | 0.5 | 2 | 0.125 | 0.5 |
| E. coli ATCC 11229 | 2.5 | 0.25 | >128 | 0.625 | 8 | 0.125 | 0.25 |
| E. coli ATCC 25922 | 10 | 0.25 | >128 | 2.5 | 4 | 0.125 | 0.25 |
| K. pneumoniae ATCC 4352 | >30 | 0.25 | >128 | 10 | 4 | 0.125 | 0.5 |
| K. pneumoniae ATCC 33495 | >30 | 0.25 | >128 | 10 | 4 | 0.125 | 0.25 |
| P. aeruginosa ATCC 27853 | 10 | 0.5 | >128 | 5 | 2 | 0.125 | 1 |
| P. aeruginosa PA01 | 2.5 | 0.5 | >128 | 1.25 | 0.25 | 0.125 | 1 |