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. 2017 Sep 5;12(9):e0182118. doi: 10.1371/journal.pone.0182118

Table 2. Univariate associations between leukocytosis and outcomes.

Variable WBC<11k WBC> = 11k n p-value
n n
10116 863 10979
Operative Time 263.150 103.621 259.424 111.314 10976 0.343  
Blood Transfusions 3311/10116 32.7% 303/863 35.1% 10979 0.164  
Total Hospital Stay (days) 9.878 9.786 11.648 8.722 10960 <0.001  
30-Day Mortality 253/10116 2.5% 33/863 3.8% 10979 0.026 *
Wound Complications (composite) 405/10116 4.0% 47/863 5.4% 10979 0.050  
    Superficial Incisional SSI 311/10116 3.1% 31/863 3.6% 10979 0.460  
    Deep Incisional SSI 44/10116 0.4% 5/863 0.6% 10979 0.730  
    Organ/Space SSI 29/10116 0.3% 6/863 0.7% 10979 0.084  
    Wound Disruption 42/10116 0.4% 11/863 1.3% 10979 0.001 *
Medical Complications (composite) 1513/10116 15.0% 197/863 22.8% 10979 <0.001 *
    Unplanned Reintubation 343/10116 3.4% 39/863 4.5% 10979 0.101  
    Pulmonary Embolism 60/10116 0.6% 10/863 1.2% 10979 0.075  
    On Ventilator > 48 Hours 604/10116 6.0% 102/863 11.8% 10979 <0.001 *
    Progressive Renal Insufficiency 90/10116 0.9% 11/863 1.3% 10979 0.341  
    Acute Renal Failure 178/10116 1.8% 26/863 3.0% 10979 0.013 *
    Urinary Tract Infection 197/10116 1.9% 19/863 2.2% 10979 0.698  
    Stroke/CVA 171/10116 1.7% 24/863 2.8% 10979 0.028 *
    Coma Greater Than 24 Hours 22/10116 0.2% 4/863 0.5% 10979 0.288  
    Cardiac Arrest Requiring CPR 209/10116 2.1% 15/863 1.7% 10979 0.597  
    Myocardial Infarction 54/10116 0.5% 6/863 0.7% 10979 0.706  
    Pneumonia 365/10116 3.6% 54/863 6.3% 10979 <0.001 *
    Deep Venous Thrombosis 149/10116 1.5% 25/863 2.9% 10979 0.002 *
    Sepsis 170/10116 1.7% 26/863 3.0% 10979 0.007 *
    Septic Shock 125/10116 1.2% 13/863 1.5% 10979 0.599  

Univariate associations between leukocytosis (>11,000 white blood cell count per microliter) and outcomes. Continuous variables are expressed as a mean and standard deviation, while categorical variables are expressed as a proportion and percentage. SSI = Surgical Site Infection; CVA = Cerebrovascular Accident; CPR: Cardiopulmonary Resuscitation

* indicates statistically significant p-values at the 0.05 significance level.