Table 4. Relationship between current use of fluoroquinolones and risk of perforation associated with different anatomic sites.

	Effect estimate matched on age-group, gender, and year (RR, 95% confidence interval)	Effect estimate adjusted by disease risk score (RR, 95% confidence interval)	Effect estimate matched by disease risk score (RR, 95% confidence interval)
Gastric perforation	2.18 (1.86–2.55)***	1.92 (1.63–2.25)***	1.85 (1.42–2.43)***
Small or large intestinal perforation	1.84 (0.87–3.90)	1.44 (0.64–3.24)	3.00(0.57–15.96)

*** refers to p<0.001

RR refers to rate ratio.