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. 2017 Sep 5;6:e24196. doi: 10.7554/eLife.24196

Figure 2. Distribution of DENV serotypes and genotypes sequenced in CYD14 and CYD15 vaccine trials by country.

Numbers in parentheses indicate the total number of samples of each genotype for which complete or partial E gene sequences were obtained.

Figure 2.

Figure 2—figure supplement 1. Genotype assignment of DENV-1 E gene sequences obtained from VCD samples in CYD14 and CYD15.

Figure 2—figure supplement 1.

Phylogenetic trees showing the distribution of DENV-1 genotypes for which E genes were sequenced in CYD14 and CYD15 vaccine trials. E gene sequences were aligned with up to five publically available reference sequences of every known human DENV-1 genotype and a maximum likelihood phylogeny was constructed. Genotypes were assigned when sequences fell into a known genotype lineage with high bootstrap support. Bootstrap support values for nodes > 75% are indicated. Black dots at the tips indicate CYD14 sequences, grey dots indicate CYD15 sequences, and purple stars indicate the DENV CYD-TDV vaccine sequence for each serotype.
Figure 2—figure supplement 2. Genotype assignment of DENV-2 E gene sequences obtained from VCD samples in CYD14 and CYD15.

Figure 2—figure supplement 2.

Phylogenetic trees showing the distribution of DENV-2 genotypes for which E genes were sequenced in CYD14 and CYD15 vaccine trials. E gene sequences were aligned with up to five publically available reference sequences of every known human DENV-2 genotype and a maximum likelihood phylogeny was constructed. Genotypes were assigned when sequences fell into a known genotype lineage with high bootstrap support. Bootstrap support values for nodes > 75% are indicated. Black dots at the tips indicate CYD14 sequences, grey dots indicate CYD15 sequences, and purple stars indicate the DENV CYD-TDV vaccine sequence for each serotype.
Figure 2—figure supplement 3. Genotype assignment of DENV-3 E gene sequences obtained from VCD samples in CYD14 and CYD15.

Figure 2—figure supplement 3.

Phylogenetic trees showing the distribution of DENV-3 genotypes for which E genes were sequenced in CYD14 and CYD15 vaccine trials. E gene sequences were aligned with up to five publically available reference sequences of every known human DENV-3 genotype and a maximum likelihood phylogeny was constructed. Genotypes were assigned when sequences fell into a known genotype lineage with high bootstrap support. Bootstrap support values for nodes > 75% are indicated. Black dots at the tips indicate CYD14 sequences, grey dots indicate CYD15 sequences, and purple stars indicate the DENV CYD-TDV vaccine sequence for each serotype.
Figure 2—figure supplement 4. Genotype assignment of DENV-4 E gene sequences obtained from VCD samples in CYD14 and CYD15.

Figure 2—figure supplement 4.

Phylogenetic trees showing the distribution of DENV-4 genotypes for which E genes were sequenced in CYD14 and CYD15 vaccine trials. E gene sequences were aligned with up to five publically available reference sequences of every known human DENV-5 genotype and a maximum likelihood phylogeny was constructed. Genotypes were assigned when sequences fell into a known genotype lineage with high bootstrap support. Bootstrap support values for nodes > 75% are indicated. Black dots at the tips indicate CYD14 sequences, grey dots indicate CYD15 sequences, and purple stars indicate the DENV CYD-TDV vaccine sequence for each serotype.