Table IV.

Adverse events in patients ≥65 years of age vs. younger.^a,b

	Older (≥65 years)	Younger (%)	P-value
Neutropenia	31	29	0.02
Fatigue	15	5	0.01
Infection	9	4	0.03
Stomatitis	6	1	0.04
Hypotension	2	0	0.04
Renal failure	2	0	0.02
Dyspnea	3	1	0.51
Thrombocytopenia	9	7	0.17
Vomiting	12	10	0.99
Diarrhea	13	10	0.39

^aAll adverse events are grade 3 or greater unless otherwise specified.

^bAdverse events over all chemotherapy cycles are reported.

^cP-values are derived from logistic regression analyses, adjusted for performance score and gender and stratified by individual study; no major differing conclusions arose based on univariate analyses.