Table 3.
Obesity was not associated with seroconversion and seroprotection levels in participants with confirmed influenza and ILI
| Healthy Weight (BMI 18.5–24.9) | Overweight (BMI 25–29.9) | Obese (BMI ≥ 30) | Total | |||
|---|---|---|---|---|---|---|
| A/H1N1 California/pdm2009 | a Seroconversion | 4-Fold Increase or greater | 43% | 38% | 41% | 41% |
| b Seroprotection | HAI ≥ 40 | 71% | 79% | 68% | 70% | |
| HAI ≥ 80 | 64% | 31% | 50% | 49% | ||
| HAI ≥ 160 | 36% | 13% | 25% | 24% | ||
| HAI ≥ 320 | 14% | 6% | 11% | 11% | ||
| Nc | 14 | 16 | 44 | 74 | ||
| A H3N2 Texas 50/2012 | Seroconversion | 4-Fold Increase or greater | 50% | 44% | 46% | 46% |
| Seroprotection | HAI ≥ 40 | 86% | 69% | 82% | 80% | |
| HAI ≥ 80 | 57% | 44% | 55% | 53% | ||
| HAI ≥ 160 | 43% | 25% | 32% | 32% | ||
| HAI ≥ 320 | 14% | 6% | 11% | 11% | ||
| Nc | 14 | 16 | 44 | 74 | ||
| A/H3N2 Switzerland 9715293/2013 | Seroconversion | 4-Fold Increase or greater | 67% | 56% | 32% | 44% |
| Seroprotection | HAI ≥ 40 | 67% | 100% | 60% | 70% | |
| HAI ≥ 80 | 33% | 78% | 28% | 40% | ||
| HAI ≥ 160 | 11% | 33% | 8% | 14% | ||
| HAI ≥ 320 | 11% | 11% | 4% | 7% | ||
| c N | 9 | 9 | 25 | 43 |
a
Seroconversion is defined as a ≥4-fold increase in HAI titer 25–35 days post vaccination from pre-vaccination titer.
b
Seroprotection is typically defined as an HAI of ≥40, however multiple cut-off points were assessed as indicated. There were no significant associations between weight and the odds of seroconversion for the multiple cut-off points considered.
c
N is number of subjects by column and varies by virus as A/H3N2/Switzerland/9715293 was not assessed in participants from the 2013–2014 influenza vaccine season.