Table 3.

Associations between childhood body mass index at age 3; and body mass index trajectories across ages 3 to 38; and endothelial function at age 38.

	A. Controlled for sex			B. Controlled for sex and childhood socio-economic status
	FRHI ratios, Mean (se)	β (95% CI)	p	FRHI ratios, Mean (se)	β (95% CI)	p
BMI, age 3 (n=822)
Normal (n=697, 84.8%)	0.62 (0.01)	–		0.62 (0.01)	–
>1 standard deviation above mean (n=125, 15.2%)	0.52 (0.03)	−0.10 (−0.17 – −0.03)	0.005	0.52 (0.03)	−0.10 (−0.17 – −0.03)	0.007
BMI trajectories, age 3–38 (n=905)*
Normal (n=375, 41.4%)*	0.66 (0.02)	–		0.66 (0.02)	–
Overweight (n=374, 41.3%)*	0.58 (0.02)	−0.08 (−0.14 – −0.04)	0.002	0.58 (0.02)	−0.08 (−0.13 – −0.03)	0.003
Obese (n=135, 14.9%)*	0.53 (0.03)	−0.13 (−0.20 – −0.06)	<0.001	0.53 (0.03)	−0.13 (−0.21 – −0.06)	<0.001
Morbidly obese (n=21, 2.3%)*	0.49 (0.08)	−0.17 (−0.33 – −0.01)	0.032	0.49 (0.08)	−0.17 (−0.34 – −0.01)	0.033

Abbreviations: BMI, body mass index; CI, Confidence Interval; FHRI, Framingham Reactive Hyperemia Index; se, standard error. Associations in Panel A are controlled for sex. Associations in Panel B are controlled for sex and childhood socio-economic status. Significant associations (p<0.05) are in bold.

^*Numbers in trajectory groups among those with endothelial function data differ slightly from those in the full sample reported in Figure 1.