Table 7.

Summaries of performance statistics of presepsin, procalcitonin, and C-reactive protein for diagnosing sepsis

Category	Biomarkers	Number of studies	Number of patients	Pooled sensitivity	Pooled specificity	AUC	Pooled DOR
All	Presepsin	13	2915	0.84 (0.79–0.88)	0.75 (0.64–0.84)	0.87 (0.84–0.90)	16 (8–30)
	Procalcitonin	13	2915	0.78 (0.72–0.83)	0.79 (0.73–0.85)	0.86 (0.82–0.88)	14 (8–23)
All	Presepsin	7	1204	0.83 (0.76–0.88)	0.70 (0.55–0.81)	0.85 (0.81–0.88)	11 (7–18)
	C-reactive protein	7	1204	0.77 (0.53–0.91)	0.79 (0.62–0.89)	0.85 (0.82–0.88)	13 (5–36)
ED	Presepsin	6	1822	0.83 (0.68–0.92)	0.83 (0.67–0.92)	0.90 (0.87–0.92)	24 (5–113)
	Procalcitonin	6	1822	0.79 (0.68–0.87)	0.83 (0.72–0.91)	0.88 (0.85–0.90)	19 (7–52)
ICU	Presepsin	5	452	0.88 (0.82–0.92)	0.58 (0.42–0.73)	0.87 (0.84–0.90)	10 (5–18)
	Procalcitonin	5	452	0.75 (0.68–0.81)	0.75 (0.65–0.83)	0.82 (0.78–0.85)	9 (6–15)
Sepsis-1/2	Presepsin	7	2076	0.86 (0.76–0.91)	0.79 (0.60–0.91)	0.90 (0.87–0.92)	23 (7–77)
	Procalcitonin	7	2076	0.80 (0.72–0.87)	0.83 (0.75–0.89)	0.89 (0.86–0.91)	20 (9–45)
Sepsis-1/2	Presepsin	3	694	0.86 (0.75–0.93)	0.69 (0.33–0.90)	0.87 (0.83–0.91)	16 (6–38)
	C-reactive protein	3	694	0.86 (0.44–0.98)	0.85 (0.63–0.95)	0.91 (0.86–0.93)	34 (9–127)