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TcCRT participates in three important mechanisms related to T. cruzi infection. (A) TcCRT, translocated and secreted by the parasite, binds to C1 or MBL or L-Ficolin inactivating the CP and LP of complement system. (B) TcCRT binds C1 on the area of flagellar emergence. The TcCRT/C1q complex is recognized by CRT on the host cell surface (cC1qR), promoting host cell infectivity. (C) TcCRT has anti-angiogenic and anti-tumor growth properties.
