Table 3.
Comparison of the effect of rMASP-1 and other endothelial cell activators (TNFα, thrombin, histamine, LPS).
| Functional classification | rMASP-1 | TNFα | TR | HA | LPS |
|---|---|---|---|---|---|
| Up-regulated | |||||
| Adhesion | SELE | x | x | x | x |
| VCAM1 | x | x | x | x | |
| Cytokines and growth factors | CXCL8 | x | x | x | x |
| CXCL1 | x | x | x | x | |
| CXCL3 | x | x | x | x | |
| IL11 | x | x | |||
| CXCL2 | x | x | x | x | |
| FGF12 | |||||
| KITLG | x | x | |||
| Signaling | GHSR | x | |||
| NFKBID | x | x | |||
| TLR2 | x | ||||
| BIRC3 | x | x | x | x | |
| BDKRB2 | x | x | |||
| TGFBR1 | x | x | x | ||
| Other | KDM6B | x | x | x | |
| F3 | x | x | x | x | |
| HSPB2 | x | ||||
| PRG3 | x | ||||
| SUM | 10 | 13 | 12 | 15 | |
| Down-regulated | |||||
| Cytokines and growth factors | IL2 | x | |||
| Signaling | CREB3L3 | x | |||
| ISL1 | x | ||||
| CCR3 | x | ||||
| FOXP3 | x | ||||
| EDNRB | x | x | x | x | |
| GPR77 | x | x | x | ||
| IL17RB | |||||
| Other | LBP | ||||
| CHI3L1 | x | x | |||
| PGLYRP1 | x | ||||
| SUM | 1 | 4 | 2 | 8 | |
TNFα: tumor necrosis factor alpha, TR: thrombin, HA: histamine, LPS: lipopolysaccharide.