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. 2017 Sep 1;10:280. doi: 10.3389/fnmol.2017.00280

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Copyright © 2017 Saré, Harkless, Levine, Torossian, Sheeler and Smith.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Habituation effect in control and Fmr1 knockout (KO) mice across the 6-day testing period in the light and dark phases. Points are the means ± standard error of the mean (SEM). (A) At P21, there were no differences in genotype or in day in either phase. (B) At P70, the day × phase interaction was statistically significant (p < 0.001). Post hoc t-tests indicate that Day 1 differed from all other days in the light phase only. This habituation was not affected by genotype. (C) At P180, the day × phase interaction was statistically significant (p < 0.001). Post hoc t-tests indicate that Day 1 differed from all other days in the light phase only. This was not affected by genotype.