Table 1.
Age-, sex- and pretest-adjusted means of PAPP-A2 concentration (pg/mL) over lifestyle and medical characteristics.
| N | % | PAPP-A2 conc. (pg/mL) | p-valueb | |||
|---|---|---|---|---|---|---|
| meana | 95% CI | |||||
| Sex | 0.05 | |||||
| Men | 157 | 40.6 | 261 | (243–280) | ||
| Women | 230 | 59.4 | 283 | (268–299) | ||
| Age group | 0.03 | |||||
| < 30 y | 58 | 15.0 | 241 | (211–270) | ||
| 30- < 40 y | 45 | 11.6 | 252 | (218–285) | ||
| 40- < 50 y | 67 | 17.3 | 268 | (240–295) | ||
| 50- < 60 y | 122 | 31.5 | 277 | (256–298) | ||
| ≥ 60 y | 95 | 24.5 | 298 | (275–321) | ||
| Smoking statusc | 0.34 | |||||
| never | 203 | 52.5 | 274 | (257–290) | ||
| current | 85 | 22.0 | 283 | (258–308) | ||
| former | 98 | 25.3 | 259 | (236–282) | ||
| Alcohol consumptionc | 0.04 | |||||
| never/special occ. | 86 | 22.2 | 296 | (272–321) | ||
| 1–4x month | 165 | 42.6 | 258 | (238–277) | ||
| ≥ 2x week | 135 | 34.9 | 274 | (253–294) | ||
| Osteoporosisc,d | 0.59 | |||||
| no | 371 | 95.9 | 272 | (258–285) | ||
| yes | 14 | 3.6 | 288 | (229–347) | ||
| Diabetesd | 0.10 | |||||
| no | 368 | 95.1 | 270 | (257–283) | ||
| yes | 19 | 4.9 | 314 | (263–364) | ||
| Autoimmune diseasesc,d | 0.89 | |||||
| no | 376 | 97.2 | 272 | (259–286) | ||
| yes | 9 | 2.3 | 267 | (194–340) | ||
| Inflammatory bowel diseasec,d | 0.03 | |||||
| no | 378 | 97.7 | 271 | (258–284) | ||
| yes | 5 | 1.3 | 378 | (282–475) | ||
| Impaired kidney functione | 0.45 | |||||
| no | 372 | 96.1 | 272 | (258–285) | ||
| yes | 15 | 3.9 | 294 | (237–351) | ||
PAPP-A2, pregnancy-associated plasma protein-A2; conc., concentration; CI, confidence interval; aadjusted for age (continuously), pretest and sex (where appropriate). bANOVA. cNumbers do not add up to 100% because of missings. dInformation on diseases was self-reported by the participants. eImpaired kidney function is defined as an estimated glomerular filtration rate ≤ 60 mL/min (calculated from measured serum creatinine concentration according to the MDRD formula by Levey et al.11).